Analytical Chemistry
Analytical Chemistry at Cormica
We understand the critical role that analytical chemistry plays in the development, validation, and manufacturing of pharmaceutical and medical device products. Our world renowned laboratories, equipped with cutting-edge technology and staffed by seasoned experts, are dedicated to ensuring the highest standards of quality and safety in every project we undertake.
Our comprehensive range of analytical chemistry services is designed to meet the diverse needs of the pharmaceutical and medical device industries. From Advanced Separation Sciences to X-Ray Diffraction, our services encompass a wide array of critical testing and analysis techniques. With certifications in GMP, GLP, and ISO 17025, you can have complete confidence in the integrity and reliability of our analytical data.
Our Analytical Chemistry Services
PHYSICAL & CHEMICAL CHARACTERISATION:
- Advanced Separation Sciences
- Residual Solvent Assay
- HPLC
- Degradation Studies
- Residual Solvent Assay
- HPLC
- Pharmacopeial & Monograph Methods
- Physicochemical Testing
- Rheological Characterisation
- Solid State Analysis – Thermal and BET / Porosity
- X-Ray Diffraction
PARTICLE SIZE, SHAPE, COMPOSITION & ASSOCIATION:
- Particulate Matter Characterisation
- Particle / Powder Properties & Characterisation
QC RELEASE TESTING:
- Advanced Separation Sciences
- Residual Solvent Assay
- HPLC
- Cannabis and Hemp Testing
- Contaminants & Foreign Bodies
- Determination of Nitrosamine
- Particulate Matter Characterisation
- Pharmacopeial & Monograph Methods
- Residual Solvent Assay
- Solid State Analysis – Thermal and BET / Porosity
- X-Ray Diffraction
GENERICS SUPPORT, IVBE:
- Degradation Studies  
- Particulate Matter Characterisation
- Pharmacopeial & Monograph Methods
- Residual Solvent Assay
- Solid State Analysis – Thermal and BET / Porosity
- X-Ray Diffraction
METHOD DEVELOPMENT, VALIDATION & TRANSFER:
- Advanced Separation Sciences
- ANDA Generic Pharmaceutical Development
- Chemical Characterisation
- Degradation Studies  
- Determination of Nitrosamine
- Residual Solvent Assay
- Rheological Characterisation
- Solid State Analysis – Thermal and BET / Porosity
- X-Ray Diffraction
PRE-FORMULATION, SOLID FORM OPTIMISATION:
- Chemical Characterisation
- Degradation Studies  
- Determination of Nitrosamine
- Rheological Characterisation
GLP PHYSICO-CHEMICAL PROPERTIES:
- Advanced Separation Sciences
- Chemical Characterisation
EXTRACTABLES & LEACHABLES, MIGRATION, PACKAGING:
- Advanced Separation Sciences
- CO Analysis
- CO2 Analysis
- O3 Analysis
- Particulate Emission in Gas Pathway
- Volatile Organic Compounds in Gas Pathway
- Leachables in Condensate on Gas Pathway Devices
- Particulate Matter Characterisation
- Product Safety Registration
- Residual Solvent Assay
- Single Use Technology Residual Analysis
GLP CHARACTERISATION, PURITY PROFILING & REACH:
- Advanced Separation Sciences
- Chemical Characterisation
- Degradation Studies  
Manufacturing Support, IPCs:
- Advanced Separation Sciences
- ANDA Generic Pharmaceutical Development
- Chemical Characterisation
- Contaminants & Foreign Bodies
- Degradation Studies  
- Determination of Nitrosamine
- Particulate Matter Characterisation
- Pharmacopeial & Monograph Methods
- Residual Solvent Assay
- Solid State Analysis – Thermal and BET / Porosity
- X-Ray Diffraction
GMP & GLP STABILITY STUDIES:
- Advanced Separation Sciences
- Chemical Characterisation
- Determination of Nitrosamine
- Stability studies
OCCUPATIONAL HYGIENE, CLEANING VALIDATION & VERIFICATION:
- Advanced Separation Sciences
- Chemical Characterisation
- Contaminants & Foreign Bodies
- Cleaning Validation and Verification
- Foreign Particulate Matter Characterisation
Learn More:
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Our Analytical Chemistry Technical Resources
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Our Analytical Equipment​
Separation Sciences
Separation Sciences - Bioanalysis
Synthetic Chemistry - Selected
Physical Characterisation – Size and Shape
Physical Characterisation
Physical Characterisation – Biophysical Analysis
Elemental, Raw Materials, Other
Pre-Formulation / Formulation / Sample Prep
Separation Sciences
| Vendor | Description | Model | GMP / GLP |
|---|---|---|---|
| Thermo Scientific | uHPLC – PDA | Ultimate 3000 | ✔ |
| uHPLC – Refractive Index | Ultimate 3000 | ✔ | |
| uHPLC – Fluorescence | Ultimate 3000 | ✔ | |
| uHPLC – CAD | Ultimate 3000 | ✔ | |
| uHPLC – Electrochemical | Ultimate 3000 | ✔ | |
| uHPLC – UV/MS/MS | Vanquish PDA + Altis TSQ | ✔ | |
| uHPLC – UV/MS/MS | Vanquish PDA + Fortis TSQ | ✔ | |
| uHPLC – UV/MS/MS | Vanquish PDA + iSQ | ✔ | |
| Waters | HPLC – PDA | Alliance 2695 | ✔ |
| HPLC – ELS/D x 2 | Alliance 2695 | ✔ | |
| HPLC – Refractive Index | Alliance 2695 | ✔ | |
| Perkin Elmer | GC – FID (Head space & Liquid injection) | Autosystem XL | GMP |
| GC – FID (Head space & Liquid injection) | Clarus 400 | GMP | |
| GC – FID (Liquid injection) | Trace 1310 | ✔ | |
| GC – FID and MS (Liquid injection) | Trace 1310 with iSQ | ✔ | |
| GC – FID and MS/MS (Head space & Liquid injection plus SPME) | Evo 8000 with TSQ, TriPlus Autosampler | ✔ | |
| Metromh | Ion Chromatography – CD, PAD, Conductivity, Cations | 940 Pro with HPG | ✔ |
| Malvern Panalytical | Chromatography – SEC / GPC | OmniSEC Reveal & Resolve: UV, Viscosity, RI & LALS2 | ✔ |
Separation Sciences - Bioanalysis
| Vendor | Description | Type | GMP / GLP |
|---|---|---|---|
| Agilent | GC – FID and MS (Head space & Liquid injection) | 5977A | GLP |
| Sciex | uHPLC-MS/MS | 6500 | GLP |
| 2D-uHPLC-MS/MS (MRM and MRM³) | 6500 QTrap® | GLP | |
| 2D-uHPLC-MS/MS (MRM and MRM³) + SelexION | 6500 QTrap® | GLP | |
| Thermo Scientific | uHPLC – UV/Vis (3D data acquisition capability) | Vanquish Flex | GLP |
| Waters | uHPLC – PDA (liquid cell RAD detectors across D2C) | Acquity Arc | Non-GXP |
Synthetic Chemistry - Selected
| Vendor | Description | Vendor | Description |
|---|---|---|---|
| Agilent | 7890 HS-GC/MSD | Jeol | NMR ECX-300 MHz |
| GC-MS/MS-FID (various) | NMR ECX-400 MHz | ||
| LC-MS/MS (various) | NMR ECZ-400 MHz (GMP) | ||
| 1100 GPC | Schimadzu | uHPLC / SFC with PAD & MS | |
| Bruker | NMR Advance III HD 400 MHz | Waters | AutoPurification HPLC / MS for Mass-directed impurity isolation |
Physical Characterisation – Size and Shape
| Vendor | Description | Model | GMP / GLP |
|---|---|---|---|
| Malvern Panalytical | Particle Size & Counting – Resonant Mass | Archimedes | GMP |
| Particle Size Analysis – Laser Diffraction | Mastersizer 3000 x 2: Hydro SV, Hydro MV, Hydro EV & Aero S | ✔ | |
| Particle Size Analysis – Laser Diffraction | Mastersizer 2000: Hydro SM, Hydro S & Sirocco | GMP | |
| Particle Size, Shape, Optical & Raman Microscopy, MDRS | Morphologi4 ID x 5 | ✔ | |
| Spray Analysis – Nasal, DPI, MDI, Aerosols | Spraytec | ✔ | |
| Particle Size Analysis, DLS & Zeta Potential | Zetasizer Ultra Red | ✔ | |
| Nanoparticle Tracking & Counting | NanoSight NS3000 | ✔ | |
| Microtrac | Particle Size Analysis – Laser Diffraction | S3500 with ASVR & USVR Wet Dispersers | ✔ |
| Particle Measuring Systems | Particle Counting USP <788> & USP <729> | APSS 2000 | ✔ |
| Particle Size Analysis – Laser Diffraction, Dry Powder & Suspension | HELOS KF Vario / RODOS T4.1 with VIBRI & ASPIROS Dosing | ✔ | |
| Sympatec | Particle Size Analysis – Laser Diffraction, Dry Powder & Suspension | HELOS BR / RODOS L with VIBRI & ASPIROS Dosing | ✔ |
Physical Characterisation
| Vendor | Description | Model | GMP / GLP |
|---|---|---|---|
| Bruker | X-Ray Diffraction | D8 Advance, with LynxEye Detector | GMP |
| Jasco | Fourier Transform Infrared Spectroscopy | FT/IR-4600 CFR with ATR, KBr Disc, Liquid, Nujol Mull | ✔ |
| Malvern Panalytical | X-Ray Diffraction | Empyrean S3, High Throughput & Environmental Stage | ✔ |
| Malvern Panalytical | X-Ray Diffraction | Aeris Research Edition | ✔ |
| Micromeritics | Porosity and Specific Surface Area Analysis (BET SSA) | TriStar 3000 and TriStar II 3020 FlowPrep 060 (x 3) | GMP |
| Perkin Elmer | Differential Scanning Calorimetry | DSC 8000: mDSC, Hyper DSC | ✔ |
| Perkin Elmer | Thermogravimetric Analysis | TGA 8000 | ✔ |
| SMS | Dynamic Vapour Sorption, Water | Discovery Aqua | ✔ |
| TA Instruments | Isothermal Calorimetry | TAM III: RH Perfusion & Nano Calorimeters | GMP |
| Netsch | Rheometry | Kinexus Ultra+ | GMP |
Physical Characterisation – Biophysical Analysis
| Vendor | Description | Model | GMP / GLP |
|---|---|---|---|
| Creoptix | Grated-Coupled Interferometry (GCI) | Creoptix WAVEdelta | Non-GXP |
| Cytiva | Surface Plasmon Resonance (SPR) | Biocore T200 | Non-GXP |
| Cytiva | Surface Plasmon Resonance (SPR) | Biocore 8k | Non-GXP |
| Malvern Panalytical | Chromatography – SEC / GPC | OmniSEC Reveal & Resolve: UV, Viscosity, RI & LALS | Non-GXP |
| Malvern Panalytical | Microcalorimetry – Differential Scanning Calorimetry | MicroCAL PEAQ-DSC Automated | Non-GXP |
| Malvern Panalytical | Microcalorimetry – Isothermal Titration Calorimetry | MicroCAL PEAQ-ITC | Non-GXP |
| Malvern Panalytical | Microcalorimetry – Isothermal Titration Calorimetry | MicroCAL PEAQ-ITC Automated | Non-GXP |
| Malvern Panalytical | Nanoparticle Tracking & Counting | NanoSight NS3000 | Non-GXP |
| Malvern Panalytical | Particle Size Analysis, DLS & Zeta Potential | Zetasizer Ultra | Non-GXP |
Elemental, Raw Materials, Other
| Vendor | Description | Model | GMP / GLP |
|---|---|---|---|
| Agilent | ICP-MS | 7900 Single Quadrupole MS | ✔ |
| Endecotts | Sieve Shaker | Octagon-200 | ✔ |
| Erweka | Dissolution Testing | DT800 HH (8 bath) | ✔ |
| Erweka | USP Bulk / Tapped Volumetry | SMV102 | ✔ |
| FEI | SEM & SEM-EDX | Quanta 400 E-SEM | Non-GXP |
| Gilson | Ultrasonic Sifter | GilSonic AutoSiever | ✔ |
| Perkin Elmer | UV Spectrophotometry | Lambda 365 | ✔ |
| Hach Lange | UV Spectrophotometry | DR3900 / LT200 Heater | ✔ |
| Metromh | Autotitration | 904 Titrando & 716 DMS Titrino | ✔ |
| Metromh | Karl Fischer – Coulometric / Volumetric | 852 Combined Karl Fischer with 860 Oven & 701 KF Titrino | ✔ |
| Mettler Toledo | Moisture Balance | HR83-P x2 | ✔ |
| Suez | Total Organic Carbon | Sievers 900 | GMP |
| Thermo Scientific | ICP-OES | iCAP 6500 Duo | ✔ |
| Torsion Balance Supplies | Torsion Balance | OS Torsion Balance | ✔ |
Pre-Formulation / Formulation / Sample Prep
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| Vendor | Description | Model |
|---|---|---|
| Copley Scientific | Next Generation Impactor | NGI with Quartz Discs & Cups |
| Erweka | Disintegration Tester | ZT 221 |
| Food Pharma Systems | Microniser | Pilot Mill 2 |
| Fritsch | Nanomill (4 position) | Pulverisette 5 |
| Heidolph | Heater Shaker / Cycling Incubator | Titramax 1000 |
| Knauer | Osmometer | K-7400S |
| Leica | Benchtop Optical Microscope | DMLS |
| Metromh | pH Stat Titrator | Titrando 902 |
| Memmert | Stability Incubators, 260L | HPP260 x 3 |
| Source Bioscience | Stability Chambers, 3000L | 5902-TS x 2 |
| Spex | Ball Mixer / Mill | 8000M |
| Technobis Crystallisation Systems | Multi-reactor crystalliser (16 x 1 mL) | Crystal 16 v3 |
| Turbula | Tumble Blender (2 Litre Pail) | T2F |
| TECHNE | Sample Concentrator | FSC400D x 2 |
Additional Equipment:
- Silverston mixers
- Overhead stirrers
- Vortex mixers
- Hotplates
- Bottle rollers
- Wrist shakers
- Centrifuges
- Glove box
- Vacuum ovens
- Chamber furnace
- Rotary evaporator
- Melting point
- Analytical & Specialist balances
- pH & Conductivity meters
- Deionised water systems
- Distilled water system.
Cormica's Analytical Chemistry Labratories
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